Harlem is a beautiful, smart, and funny seventeen year old. She lives in the projects with her drug addicted parents whose addiction is so far gone Harlem must fend for herself and at times do a little hustling of her own to feed their habit. As if things can't get worse, soon Harlem 's world is turned upside down when her mother dies from a drug overdose and her father pulls the ultimate betrayal by prostituting her.

After this brutal act, Harlem is pushed into an adult world and into the hands of a crime and drug lord named Chief who gives Harlem every luxury she has ever dreamed of and more pain and suffering than she can stand. Used as a pretty object, Harlem is forced to engage in degrading and humiliating sexual acts, as well as break the law for Chief.

Things unfold when an old crush named Savior and the crime lord Stuckey show up and secrets of her mother and her life are revealed, leaving Harlem  in for an explosive surprise. A war over turf is waged between Stuckey and Chief. Harlem finds herself in the middle, leaving her to once again depend on the strength she has inside to find a way out.  Harlem on Lock  is a story of love, revenge, and redemption.

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